Athymic Nude
Hsd: Athymic Nude-Foxn1nu
Hsd: Athymic Nude-Foxn1nu/Foxn1+
Albino. Derived from a nucleus colony obtained from the National Cancer Institute, Frederick, Maryland. This immunodeficient model was originally thought to be a Balb/c congenic, but was later reported by NCI to be outbred.
Characteristics
- The nu allele on chromosome 11 is an autosomal recessive mutation
- Dysfunctional rudimentary thymus
- Litter average: 7
- Phenotypically hairless (sparse hair growth possible)
- T-cell deficient
- B-cells function normal
- No generation of cytotoxic effector cells
- No graft versus host response
- Foxn1nu/Foxn1+ heterozygotes do not show partial expression of the nu phenotype
Research use
- Oncology
- Transplantation
- Tumor cell growth
- Immunology
- Autoimmune disease
- Antibody production
- Sentinel model heterozygous - Foxn1nu/Foxn1+
Other available data
- Hematology
- Clinical chemistry
- Proven model with extensive references