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Outbred rats

Strains of outbred rats

Wistar Han®
RccHan®:WIST
HsdHan®:WIST

Albino. Derived at Biological Research Laboratories Limited (BRL), formerly RCC, now Harlan Laboratories Ltd., Fullinsdorf, Switzerland from original colony at Zentralinstitute fur Versuchstierzucht, Hannover in 1989. Transferred to Harlan Sprague-Dawley, Inc. in 1993. In 2004 Envigo acquired RCC Ltd. and new breeding stock was transferred in 2008 (nomenclature RccHanR:WIST). Unlike competitive models, the RccHanR:WIST rat has been maintained from the original nucleus of 156 breeding pairs in Hannover, Germany.

Han® is a registered trademark of Envigo.

Characteristics

  • Litter average: 9,5
  • Docile disposition
  • Global breeding and monitoring system - consistent research outcomes
  • Longer survival - reduced costs, improved study outcomes
  • Lower spontaneous tumor incidence - reduced research variables, improved animal welfare
  • Smaller body size - less compound and cost

Research use

  • Hematology
  • Clinical chemistry

Other available data

  • Toxicology
  • Teratology
  • General purpose
  • Oncology
  • Aging

 20 years of stable control data at envigo.com/toxicology

Acute to oncogenicity studies – 3, 6, 12 and 24 months

  • Survival rates
  • Growth
  • Food and water consumption
  • Clinical observations
  • Functional observation battery
  • Opthalmoscopy
  • Clinical pathology
  • P450 enzymes
  • Gross lesions and organ weights
  • Bone marrow d
  • Incidence and images of spontaneous neoplastic and nonneoplastic changes
  • Reproductive and developmental data

 

Sprague Dawley®
Hsd:Sprague Dawley® SD®

Albino. Originated by the Sprague-Dawley Company in 1925 through a series of crosses begun with a single-hooded male and six albino females of unknown origin. Current Envigo colonies are direct descendants of this original colony.

 SD® is a registered trademark of Envigo.

Characteristics

  • Most widely used outbred rat in animal research
  • Litter average: 11,0
  • Excellent reproductive performance and maternal characteristics
  • Docile disposition

Research use

  • Toxicology
  • Aging
  • Teratology
  • Oncology
  • Nutrition
  • Diet-induced obesity
  • General purpose
  • Cardiovascular
  • Neuroscience
  • Reproductive

 

Wistar Unilever
HsdCpb:WU

Albino. Descended from animals from Wistar Institute, Philadelphia, Pennsylvania. In 1932 to Glaxo Institute, UK and in 1933 to the Dutch Institution for Nutrition, Amsterdam. In 1941 to the Unilever Company Vlaardingen, the Netherlands. In 1958 transferred to TNO-CPB (now Envigo).

Characteristics

  • Litter average: 11,0

Research use

  • Teratology
  • Aging
  • General purpose
  • Nutrition
  • Oncology

 Other available data

  • Complete blood counts
  • Serum chemistry

 

Lister Hooded
HsdOla:LH

Black-hooded. From ICI, Alderley Edge in 1932 to Medical Research Council, Mill Hill, UK. In 1969 to Olac (now Envigo).

Characteristics

  • Litter average: 10,0
  • Slow growth rate

Research use

  • Behavioral studies

 

Additional strains of outbred rats

HsdBlu:LE (Long Evans)
Hsd:WI (Wistar)