Inbred mice

BALB/c

Albino. BALB/cOlaHsd mice originate from the Laboratory Animal Centre, Carshalton UK from the Jackson Laboratory, Bar Harbor, Maine in 1955. In 1976 to Olac (now Envigo).

BALB/cOlaHsd

Characteristics

Litter average: 6,0
Experimental allergic encephalomyelitis resistant
Haplotype: H-2^d

Research use

Cardiovascular
Toxicology
Aging
General studies
Monoclonal Antibody Production
Pharmacology
Teratology
Oncology

Other available data

Hematology
Clinical chemistry

C57BL/6

C57BL/6JOlaHsd
C57BL/6JRccHsd
C57BL/6NHsd

Black. C57BL/6JOlaHsd mice originate from the Jackson Laboratory, Bar Harbor, Maine. In 1974 to the Laboratory Animal Centre, Carshalton UK. To Olac in 1983 (now Envigo).

Black. C57BL/6NHsd; Derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland.

The C57BL/JRccHsd mice originate from Jackson Laboratory, Bar Harbor, Maine and were moved in 1973 to RCC Ltd. (formerly Ibm and BRL) in Fullinsdorf, Switzerland. To Harlan Laboratories through acquisition in 2004. Harlan became Envigo in 2015..

Characteristics

Litter average: 6,0
Haplotype: H-2^b
Most widely used inbred strain
Low tumor incidence
High preference for alcohol
Microphthalmia
Incidence of Hydrocephalous
C57BL/6JRccHsd subline does not carry Nnt (nicotinamid nucleotid transhydrogenázu) gene-deletion
C57BL/6JOlaHsd subline carries a deletion at the alpha synuclein locus
C57BL/6NHsd subline carries a retinal degeneration 8 mutation - rd8

Research use

Background for induced and genetically modified models
Diet induced obesity
Toxicology
Aging
Cardiovascular
Superovulation
Immunology
Drug addiction
Alcoholism
General purpose

Other available data

Hematology
Clinical chemistry

C3H

Agouti. Derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland.

C3H/HeNHsd

Characteristics

Litter average: 5,0
Haplotype: H-2^k
Carrier of the retinal degeneration mutation (Pde6b^rd1)
Normal response to LPS
Highly susceptible to Anthrax toxin

Research use

General purpose
Ocular disease
Immunology

Other available data

Clinical chemistry
Hematology

CBA/Ca

CBA/CaOlaHsd

Agouti. Obtained by the Laboratory Animal Centre, Carshalton UK from Atomic Energy Establishment, Harwell in 1956 and then to Olac in 1976 (now Envigo).

DBA/1

DBA/1OlaHsd

Dilute brown, non-agouti. Originally developed by Little. Acquired by Laboratory Animals Centre, Carshalton, United Kingdom in 1955; to Olac (now Envigo) in 1979.

Characteristics

Litter average: 4,5
Haplotype: H-2^q

Research use

Adjuvant-induced arthritis
Immunology
Inflamation

DBA/2

DBA/2OlaHsd
DBA/2JRccHsd

Dilute brown, non-agouti. Originally developed by Little. Acquired by Laboratory Animal Centre, Carshalton UK. In 1972 to Olac (now Envigo).

The DBA/2JRccHsd mice originate from Jackson Laboratory, Bar Harbor, Maine and were moved in 1974 to RCC Ltd. (formerly Ibm and BRL) in Fullinsdorf, Switzerland. To Harlan Laboratories through acquisition in 2004. Harlan became Envigo in 2015.

Characteristics

Litter average: 4,5
Haplotype: H-2^d
Dystrophic myocardial calcinosis

Research use

Progressive hearing loss
Audiogenic seizures

Other strains of inbred mice:

129
129P2/OlaHsa
129S2/SvHsd

FVB
FVB/NHan^®Hsd

SAM
SAMP6/TaHsd
SAMP8/TaHsd
SAMR1/TaHsd (control)

SJL SJL/JCrHsd

A/JOlaHsd

BiozziABH/RijHsd

C57BL/10ScSnOlaHsd

C57BL/KaLwRijHsd

CBA/JCrHsd

NIH/OlaHsd

NZB/OlaHsd

NZW/OlaHsd

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