Mutant rats

Athymic Nude
Hsd:RH-Foxn1^rnu
Hsd:RH-Foxn1^rnu/Foxn1⁺

Hooded (pigmented). Derived from animals obtained from the Rowett Research Institute, Aberdeen, Scotland.

Characteristics

• Rnu allele on chromosome 10 is an autosomal recessive mutation associated with hairlessnes and thymic aplasia
• The thymus-dependent lymph node areas are depleted of lymphocytes (T-cells)
• Phenotypically hairless (sparse hair growth possible)
• Rudimentary thymic tissue
• Increased Natural Killer (NK) cell population
• Foxn1^rnu/Foxn1⁺ heterozygotes do not show partial expression of rnu phenotype

Research use

• Oncology
• Immunology
• Xenograft and allograft transplantation

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Zucker

HsdOla:ZUCKER-Lepr^fa/Lepr^fa
HsdOla:ZUCKER - (lean)

Black, brown, brown/white, black/white. Derived from a colony obtained in 1992 from Hoffmann-la-Roche, Nutley, New Jersey.

 Additional related genotypes:

HsdHlr:ZUCKER-Leprfa/Lepr+ (code H195)

HsdHlr:ZUCKER-Lepr+/Lepr+ (code W195)

* Genetic testing (at additional cost) is required to determine Leprfa/Lepr+ or Lepr+/Lepr+ genotype.

 

Characteristics

• Lepr^fa/Lepr⁺ heterozygotes do not show partial expression of fa phenotype
• fa is an autosomal recessive mutation on chromosome 5
• Exhibit obesity at 4-5 weeks of age
• Animals have not been selectively bred to induce hyperglycemia
• Insulin-resistant
• Adipocyte hypertrophy and hyperplasia
• Hyperphagia
• Muscle atrophy
• Hyperlipemic
• Hypercholesterolemia
• Hyperinsulinemia 

Research use

• Genetix obesity
• Diabetes Type 2

Other available data

• Hematology
• Clinical chemistry
• 12-week growth