Athymic Nude
Hsd:RH-Foxn1rnu
Hsd:RH-Foxn1rnu/Foxn1+
Hooded (pigmented). Derived from animals obtained from the Rowett Research Institute, Aberdeen, Scotland.
Characteristics
- Rnu allele on chromosome 10 is an autosomal recessive mutation associated with hairlessnes and thymic aplasia
- The thymus-dependent lymph node areas are depleted of lymphocytes (T-cells)
- Phenotypically hairless (sparse hair growth possible)
- Rudimentary thymic tissue
- Increased Natural Killer (NK) cell population
- Foxn1rnu/Foxn1+ heterozygotes do not show partial expression of rnu phenotype
Research use
- Oncology
- Immunology
- Xenograft and allograft transplantation
Zucker
HsdOla:ZUCKER-Leprfa/Leprfa
HsdOla:ZUCKER - (lean)
Black, brown, brown/white, black/white. Derived from a colony obtained in 1992 from Hoffmann-la-Roche, Nutley, New Jersey.
Additional related genotypes:
HsdHlr:ZUCKER-Leprfa/Lepr+ (code H195)
HsdHlr:ZUCKER-Lepr+/Lepr+ (code W195)
* Genetic testing (at additional cost) is required to determine Leprfa/Lepr+ or Lepr+/Lepr+ genotype.
Characteristics
- Leprfa/Lepr+ heterozygotes do not show partial expression of fa phenotype
- fa is an autosomal recessive mutation on chromosome 5
- Exhibit obesity at 4-5 weeks of age
- Animals have not been selectively bred to induce hyperglycemia
- Insulin-resistant
- Adipocyte hypertrophy and hyperplasia
- Hyperphagia
- Muscle atrophy
- Hyperlipemic
- Hypercholesterolemia
- Hyperinsulinemia
Research use
- Genetix obesity
- Diabetes Type 2
Other available data
- Hematology
- Clinical chemistry
- 12-week growth