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Mutant mice

Strains of mutant mice

Athymic Nude
Hsd: Athymic Nude-Foxn1nu
Hsd: Athymic Nude-Foxn1nu/Foxn1+

Albino. Derived from a nucleus colony obtained from the National Cancer Institute, Frederick, Maryland. This immunodeficient model was originally thought to be a Balb/c congenic, but was later reported by NCI to be outbred.

Characteristics

  • The nu allele on chromosome 11 is an autosomal recessive mutation
  • Dysfunctional rudimentary thymus
  • Litter average: 7
  • Phenotypically hairless (sparse hair growth possible)
  • T-cell deficient
  • B-cells function normal
  • No generation of cytotoxic effector cells
  • No graft versus host response
  • Foxn1nu/Foxn1+ heterozygotes do not show partial expression of the nu phenotype

Resaearch use

  • Oncology
  • Transplantation
  • Tumor cell growth
  • Immunology
  • Autoimmune disease
  • Antibody production
  • Sentinel model heterozygous - Foxn1nu/Foxn1+

Other available data

  • Hematology
  • Clinical chemistry
  • Proven model with extensive references

BALB/c Nude

BALB/cOlaHsd-Foxn1nu
BALB/cOlaHsd-Foxn1nu/Foxn1+

Albino. Institute of Animal Genetics, Edinburgh to Laboratory Animals Centre, Carshalton, to GD Searle, High Wycombe, to Olac (now Envigo) in 1978.

Characteristics

  • The nu allele on chromosome 11 is an autosomal recessive mutation
  • Dysfunctional rudimentary thymus
  • Phenotypically hairless (sparse hair growth possible)
  • T-cell deficient
  • B-cells function normal
  • No generation of cytotoxic effector cells
  • No graft versus host response
  • Foxn1nu/Foxn1+ heterozygotes do not show partial expression of the nu phenotype

Resaearch use

  • Oncology
  • Transplantation
  • Tumor cell growth
  • Immunology
  • Autoimmune disease
  • Antibody production
  • Sentinel model heterozygous - Foxn1nu/Foxn1+

Other available data

  • Hematology
  • Clinical chemistry
  • Proven model with extensive references

NMRI Nude

HsdCpb:NMRI-Foxn1nu
HsdCpb:NMRI-Foxn1nu/Foxn1+

Albino. Derived from a nucleus colony obtained from the Laboratory Animals Centre, Carshalton, UK. To TNO-CPB (now Envigo) in 1972.

Characteristics

  • The nu allele on chromosome 11 is an autosomal recessive mutation
  • Dysfunctional rudimentary thymus
  • Phenotypically hairless (sparse hair growth possible)
  • T-cell deficient
  • B-cells function normal
  • No generation of cytotoxic effector cells
  • No graft versus host response
  • Foxn1nu/Foxn1+ heterozygotes do not show partial expression of the nu phenotype

Resaearch use

  • Oncology
  • Transplantation
  • Tumor cell growth
  • Immunology
  • Autoimmune disease
  • Antibody production
  • Sentinel model heterozygous - Foxn1nu/Foxn1+

Other available data

  • Hematology
  • Clinical chemistry
  • Proven model with extensive references

SCID

C.B-17/IcrHan®Hsd-Prkdcscid
C.B-17/IcrHsd-Prkdcscid

Albino. Harlan acquired from the Fox Chase Cancer Center, Philadelphia, Pennsylvania, in 1991. Harlan became Envigo in 2015.

Han® is a registered trademark of Envigo

Characteristics

  • Autosomal recessive, single nucleotide polymorphism within Prkdc gene on chromosome 16
  • Severe combined immunodeficiency affecting T- and B-cell development
  • Natural Killer (NK) cell, macrophage and granulocyte cell numbers and function are normal
  • As SCID mice age, a variable percentage become “leaky” from the spontaneous development of functional T- and B-lymphocytes
  • Highly susceptible to opportunistic viral and bacterial infection

Resaearch use

  • Oncology
  • Transplantation
  • Tumor cell growth
  • Immunology

 


SCID/Beige

C.B-17/IcrHsd-PrkdcscidLystbg

Albino. Harlan acquired from the Fox Chase Cancer Center, Philadelphia, Pennsylvania, in 1991. Harlan became Envigo in 2015.

Characteristics

  • Autosomal recessive, single nucleotide polymorphism within Prkdc gene on chromosome 16
  • Autosomal recesive, beige (bg-J) mutation on chromosome 13
  • Severe combined immunodeficiency affecting T- and B- cell development
  • Severe lymphopenia
  • Diminished Natural Killer (NK) cell activity relative to other SCID models
  • Rudimentary thymus
  • Highly susceptible to opportunistic viral and bacterial infection

Research use

  • Oncology
  • Teratology
  • Transplantation
  • Tumor cell growth
  • Immunology

Other available data

  • Proven model with extensive references

NOD.SCID

NOD.CB17-Prkdcscid/NCrHsd

Albino. Received by National Cancer Institute, Frederick, Maryland in 2004 from National Institutes of Health, Bethesda, Maryland. Harlan Laboratories acquired from National Cancer Institute in 2006. Harlan became Envigo in 2015.

Characteristics

  • Autosomal recessive, single nucleotide polymorphism within Prkds gene on chromosome 16
  • Severe combined immunodeficiency affecting T- and B- cell development
  • Natural killer (NK) cell, macrophage and granulocyte cell numbers and function are reduced
  • As SCID models, a variable percentage become leaky from the spontaneous development of functional T- and B-lymphocytes
  • Highly susceptible to opportunistic viral and bacterial infection
  • Development of autoimmune diabetes does not occur due to severe combined immunodeficiency
  • Spontaneous thymic lymphomas

Research use

  • Oncology
  • Transplantation
  • Tumor cell growth
  • Immunology

Other available data

  • Hematology
  • 12-week growth,

 

Další kmeny mutantních myší

Diabetic (db/db)
BKS.Cg-+Leprdb/+Leprdb/OlaHsd
BKS.Cg-(lean)/OlaHsd

Obese (ob/ob)
B6.V-Lepob/Lepob/OlaHsd
B6.V-(lean)/OlaHsd

Albino C57BL/6
C57BL/6/BrdCrHsd-Tyrc

SHrN™ (“Shorn”) Hairless NOD.SCID
NOD.Cg-PrkdcscidHrhr/NCrHsd

MF1 Nude
HsdOla:MF1-Foxn1nu
HsdOla:MF1-Foxn1nu/Foxn1+

NMRI Nude
HsdCpb:NMRI-Foxn1nu
HsdCpb:NMRI-Foxn1nu/Foxn1+
MRL/MpOlaHsd-Tnfrsf6LPR 
Hsd:NIHS-Lystbg-JFoxn1nuBtkxid
Hsd:NIHS-Lystbg-JFoxn1nu/Foxn1+Btkxid