Inbred rats

Brown Norway
BN/RijHsd

Brown, non-agouti. BN/RijHsd rats were derived from a nucleus colony obtained directly from the TNO Institute, the Netherlands.

Characteristics

• Litter average: 4,5
• Haplotype: RT1ⁿ
• Hyper-responsive lungs
• High incidence of bladder tumors in males

Research use

• Allergic respiratory disease
• Oncology
• Aging
• Leukemia
• Nephrology

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DA

DA/OlaHsd

Agouti. From A.R.C. Cambridge, United Kingdom; to Olac, United Kingdom, in 1979; to Harlan Laboratories, in 1992. Harlan became Envigo in 2015.

Characteristics

• Litter average: 6,0
• Haplotype: RT1^av1
• Females have a defective bile acid transport

Research use

• Experimental allergic encephalomyelitis
• Induced rheumatoid arthritis
• Oncology
• Cardiovascular
• Transplantation

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Lewis
LEW/Han^®Hsd
LEW/SsNHsd

Albino. LEW/HanRHsd rats were descended from the Central Institute for Laboratory Animal Breeding (ZfV), Hannover, Germany. In 1994 to Harlan through acquisition.

LEW/SsNHsd rats were descended from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland USA.
Han^® is a registered trademark of Envigo.

Charakteristika

• Průměr vrhu: 7,5
• Haplotype: RT1^l
• Zvýšené hladiny sérového thyroxinu, inulinu a růstového hormonu
• Dispozice k učení
• Inbrední recipient pro několik kongenních kmenů
• Vnímavý k navození autoimunních chorob

Characteristics

• Litter average: 7,5
• Haplotype: RT1^l
• Inbred recipient for several congenic strains
• Increased levels of serum thyroxine, insulin, and growth hormone
• Susceptible to induction of autoimmune disease

Research use

• Adjuvant-induced arthritis
• Transplantation
• Experimental allergic encephalomyelitis

Other available data

Clinical chemistry

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Spontaneously Hypertensive
SHR/NHsd

Albino. Derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland.

Characteristics

• Litter average: 9,4
• Haplotype: RT1^k

Research use

• Model for Hypertension and Insulin Resistance

Other available data

To maintain the phenotype of SHR/NHsd rats, ENVIGO routinely screens future breeders utilizing the tail cuff method for acceptable blood pressure levels. On request we can monitor individual rats prior to shipment (at additional cost).

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Wistar Kyoto
WKY/NHsd

Albino. Derived from a nucleus colony obtained from the National

Institutes of Health, Bethesda, Maryland

Characteristics

• Litter average: 8,4
• Haplotype: RT1^k
• Normotensive control for SHR model

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Additional strains of inbred rats

ACI/SegHsd
SR/JrHsd
SS/JrHsd
WF/NHsd