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Inbred rats

Strains of inbred rats

Brown Norway
BN/RijHsd

Brown, non-agouti. BN/RijHsd rats were derived from a nucleus colony obtained directly from the TNO Institute, the Netherlands.

Characteristics

  • Litter average: 4,5
  • Haplotype: RT1n
  • Hyper-responsive lungs
  • High incidence of bladder tumors in males

Research use

  • Allergic respiratory disease
  • Oncology
  • Aging
  • Leukemia
  • Nephrology

DA

DA/OlaHsd

Agouti. From A.R.C. Cambridge, United Kingdom; to Olac, United Kingdom, in 1979; to Harlan Laboratories, in 1992. Harlan became Envigo in 2015.

Characteristics

  • Litter average: 6,0
  • Haplotype: RT1av1
  • Females have a defective bile acid transport

Research use

  • Experimental allergic encephalomyelitis
  • Induced rheumatoid arthritis
  • Oncology
  • Cardiovascular
  • Transplantation

 

Lewis
LEW/Han®Hsd
LEW/SsNHsd

Albino. LEW/HanRHsd rats were descended from the Central Institute for Laboratory Animal Breeding (ZfV), Hannover, Germany. In 1994 to Harlan through acquisition.

LEW/SsNHsd rats were descended from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland USA.
Han® is a registered trademark of Envigo.

Charakteristika

  • Průměr vrhu: 7,5
  • Haplotype: RT1l
  • Zvýšené hladiny sérového thyroxinu, inulinu a růstového hormonu
  • Dispozice k učení
  • Inbrední recipient pro několik kongenních kmenů
  • Vnímavý k navození autoimunních chorob

Characteristics

  • Litter average: 7,5
  • Haplotype: RT1l
  • Inbred recipient for several congenic strains
  • Increased levels of serum thyroxine, insulin, and growth hormone
  • Susceptible to induction of autoimmune disease

Research use

  • Adjuvant-induced arthritis
  • Transplantation
  • Experimental allergic encephalomyelitis

Other available data

Clinical chemistry


 

Spontaneously Hypertensive
SHR/NHsd

Albino. Derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland.

Characteristics

  • Litter average: 9,4
  • Haplotype: RT1k

Research use

  • Model for Hypertension and Insulin Resistance

Other available data

To maintain the phenotype of SHR/NHsd rats, ENVIGO routinely screens future breeders utilizing the tail cuff method for acceptable blood pressure levels. On request we can monitor individual rats prior to shipment (at additional cost).


 

Wistar Kyoto
WKY/NHsd

Albino. Derived from a nucleus colony obtained from the National

Institutes of Health, Bethesda, Maryland

Characteristics

  • Litter average: 8,4
  • Haplotype: RT1k
  • Normotensive control for SHR model

 

Additional strains of inbred rats

ACI/SegHsd
SR/JrHsd
SS/JrHsd
WF/NHsd