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Inbred mice

Strains of inbred mice

BALB/c
BALB/cOlaHsd

Albino. BALB/cOlaHsd mice originate from the Laboratory Animal Centre, Carshalton UK from the Jackson Laboratory, Bar Harbor, Maine in 1955. In 1976 to Olac (now Envigo).

Characteristics

  • Litter average: 6,0
  • Experimental allergic encephalomyelitis resistant
  • Haplotype: H-2d

 

Research use

  • Cardiovascular
  • Toxicology
  • Aging
  • General studies
  • Monoclonal Antibody Production
  • Pharmacology
  • Teratology
  • Oncology

 

Other available data

  • Hematology
  • Clinical chemistry

 

C3H
C3H/HeNHsd

Agouti. Derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland.

Characteristics

  • Litter average: 5,0
  • Haplotype: H-2k
  • Carrier of the retinal degeneration mutation (Pde6brd1)
  • Normal response to LPS
  • Highly susceptible to Anthrax toxin

 

Research use

  • General purpose
  • Ocular disease
  • Immunology

 

Other available data

  • Clinical chemistry
  • Hematology

 

CBA/Ca
CBA/CaOlaHsd

Agouti. Obtained by the Laboratory Animal Centre, Carshalton UK from Atomic Energy Establishment, Harwell in 1956 and then to Olac in 1976 (now Envigo).


 

C57BL/6
C57BL/6JOlaHsd
C57BL/6JRccHsd
C57BL/6NHsd

Black. C57BL/6JOlaHsd mice originate from the Jackson Laboratory, Bar Harbor, Maine. In 1974 to the Laboratory Animal Centre, Carshalton UK. To Olac in 1983 (now Envigo).

Black. C57BL/6NHsd; Derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland.

The C57BL/JRccHsd mice originate from Jackson Laboratory, Bar Harbor, Maine and were moved in 1973 to RCC Ltd. (formerly Ibm and BRL) in Fullinsdorf, Switzerland. To Harlan Laboratories through acquisition in 2004. Harlan became Envigo in 2015..

Characteristics

  • Litter average: 6,0
  • Haplotype: H-2b
  • Most widely used inbred strain
  • Low tumor incidence
  • High preference for alcohol
  • Microphthalmia
  • Incidence of Hydrocephalous
  • C57BL/6JRccHsd subline does not carry Nnt (nicotinamid nucleotid transhydrogenázu) gene-deletion
  • C57BL/6JOlaHsd subline carries a deletion at the alpha synuclein locus
  • C57BL/6NHsd subline carries a retinal degeneration 8 mutation - rd8

 

Research use

  • Background for induced and genetically modified models
  • Diet induced obesity
  • Toxicology
  • Aging
  • Cardiovascular
  • Superovulation
  • Immunology
  • Drug addiction
  • Alcoholism
  • General purpose

 

Other available data

  • Hematology
  • Clinical chemistry

 

DBA/1
DBA/1OlaHsd

Dilute brown, non-agouti. Originally developed by Little. Acquired by Laboratory Animals Centre, Carshalton, United Kingdom in 1955; to Olac (now Envigo) in 1979.

Characteristics

  • Litter average: 4,5
  • Haplotype: H-2q

 

Research use

  • Adjuvant-induced arthritis
  • Immunology
  • Inflamation

 

DBA/2
DBA/2OlaHsd
DBA/2JRccHsd

Dilute brown, non-agouti. Originally developed by Little. Acquired by Laboratory Animal Centre, Carshalton UK. In 1972 to Olac (now Envigo).

The DBA/2JRccHsd mice originate from Jackson Laboratory, Bar Harbor, Maine and were moved in 1974 to RCC Ltd. (formerly Ibm and BRL) in Fullinsdorf, Switzerland. To Harlan Laboratories through acquisition in 2004. Harlan became Envigo in 2015.

Characteristics

  • Litter average: 4,5
  • Haplotype: H-2d
  • Dystrophic myocardial calcinosis

 

Research use

  • Progressive hearing loss
  • Audiogenic seizures

 

Other strains of inbred mice:

129
129P2/OlaHsa
129S2/SvHsd

FVB
FVB/NHan®Hsd

SAM
SAMP6/TaHsd
SAMP8/TaHsd
SAMR1/TaHsd (control)

SJL SJL/JCrHsd

A/JOlaHsd

BiozziABH/RijHsd

C57BL/10ScSnOlaHsd

C57BL/KaLwRijHsd

CBA/JCrHsd

NIH/OlaHsd

NZB/OlaHsd

NZW/OlaHsd